Scientific reference and publications on COVID-19
papers
Links to published
papers on COVID-19
Scientific reference and publications on COVID-19
On this page you can view the listed scientific publications on COVID-19.
We also suggest consulting the page LINKS TO COVID-19 WEB RESOURCES,where there are updates on the COVID-19 pandemic, and SIF DOCUMENTS ON COVID-19, where you can find pharmacological information on the drugs and therapies used in patients with COVID-19
Links to scientific papers
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9 mar 2021Acute Allergic Reactions to mRNA COVID-19 Vaccines
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8 mar 2021Approaches for Optimal Use of Different COVID-19 Vaccines - Issues of Viral Variants and Vaccine Efficacy
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8 mar 2021Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19A - Randomized Clinical Trial
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2 mar 2021The Johnson & Johnson Vaccine for COVID-19
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2 mar 2021Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2
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1 mar 2021SARS-CoV-2 Vaccines
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1 mar 2021Pregnant People’s Paradox—Excluded From Vaccine Trials Despite Having a Higher Risk of COVID-19 Complications
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1 mar 2021Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19A Systematic Review and Meta-analysis
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22 feb 2021The US Regulatory System and COVID-19 Vaccines - The Importance of a Strong and Capable FDA
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22 feb 2021CDC Studies Underscore Continued Importance of Masks to Prevent Coronavirus Spread
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22 feb 2021Medicaid and COVID-19 Vaccination—Translating Equitable Allocation Into Equitable Administration
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22 feb 2021Taking Vaccine to Where the Virus Is—Equity and Effectiveness in Coronavirus Vaccinations
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22 feb 2021Follow-up Survey of US Adult Reports of Mental Health, Substance Use, and Suicidal Ideation During the COVID-19 Pandemic, September 2020
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22 feb 2021High-Income Countries Have Secured the Bulk of COVID-19 Vaccines
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19 feb 2021The Price of Success—How to Evaluate COVID-19 Vaccines When They’re Available Outside of Clinical Trials
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18 feb 2021Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19A - Randomized Clinical Trial
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18 feb 2021Vitamin D3 to Treat COVID-19 - Different Disease, Same Answer
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15 feb 2021Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021
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12 feb 2021Assessment of Outpatient Dispensing of Products Proposed for Treatment or Prevention of COVID-19 by US Retail Pharmacies During the Pandemic
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12 feb 2021SARS-CoV-2 Viral Variants—Tackling a Moving Target
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11 feb 2021Involving Pregnant Individuals in Clinical Research on COVID-19 Vaccines
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11 feb 2021Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2
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9 feb 2021Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin
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9 feb 2021Protecting Pregnant Women and Their Infants From COVID-19: Clues From Maternal Viral Loads, Antibody Responses, and Placentas
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9 feb 2021Pregnancy, Postpartum Care, and COVID-19 Vaccination in 2021
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9 feb 2021COVID-19 Vaccination in Pregnant and Lactating Women
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8 feb 2021Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19A Randomized Clinical Trial
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3 feb 2021SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants
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25 gen 2021Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19 - A Randomized Clinical Trial
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25 gen 2021Change in Reported Adherence to Nonpharmaceutical Interventions During the COVID-19 Pandemic, April-November 2020
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22 gen 2021Neutralizing Monoclonal Antibody for Mild to Moderate COVID-19
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22 gen 2021Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19A Randomized Clinical Trial
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22 gen 2021Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine
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18 gen 2021Funding of Pharmaceutical Innovation During and After the COVID-19 Pandemic
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14 gen 2021The COVID-19 Pandemic—An Opportune Time to Update Medical Licensing
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14 gen 2021Modernize Medical Licensing, and Credentialing, Too—Lessons From the COVID-19 Pandemic
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4 gen 2021The Hidden Epidemic of Opioid Overdoses During the Coronavirus Disease 2019 Pandemic
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30 dic 2020National Trends in the US Public’s Likelihood of Getting a COVID-19 Vaccine—April 1 to December 8, 2020
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30 dic 2020Reassuring the Public and Clinical Community About the Scientific Review and Approval of a COVID-19 Vaccine
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30 dic 2020Mandating COVID-19 Vaccines
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30 dic 2020Building Trust to Achieve Confidence in COVID-19 Vaccines
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30 dic 2020Internet Searches for Unproven COVID-19 Therapies in the United States
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28 dic 2020Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results
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28 dic 2020Mask Exemptions During the COVID-19 Pandemic—A New Frontier for Clinicians
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28 dic 2020Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) - A Review
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22 dic 2020Assessment of Filled Buprenorphine Prescriptions for Opioid Use Disorder During the Coronavirus Disease 2019 Pandemic
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21 dic 2020Evaluating SARS-CoV-2 Vaccines After Emergency Use Authorization or Licensing of Initial Candidate Vaccines
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21 dic 2020Behaviorally Informed Strategies for a National COVID-19 Vaccine Promotion Program
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21 dic 2020Changes in Outpatient Buprenorphine Dispensing During the COVID-19 Pandemic
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21 dic 2020Treatment of Opioid Use Disorder Among Commercially Insured Patients in the Context of the COVID-19 Pandemic
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21 dic 2020The Risks of Prescribing Hydroxychloroquine for Treatment of COVID-19—First, Do No Harm
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15 dic 2020The Ethics of Continuing Placebo in SARS-CoV-2 Vaccine Trials
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11 dic 2020Filtration Efficiency of Face Masks Used by the Public During the COVID-19 Pandemic
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11 dic 2020Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
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11 dic 2020Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the COVID-19 Pandemic
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9 dic 2020Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets
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9 dic 2020Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
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2 dic 2020Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19
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1 dic 2020The Colchicine Debacle Revisited
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30 nov 2020Clinical, Laboratory, and Interferon-Alpha Response Characteristics of Patients With Chilblain-like Lesions During the COVID-19 Pandemic
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30 nov 2020Study Aims to Identify Drugs That Could Be Repurposed for COVID-19
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30 nov 2020Antibodies, Immunity, and COVID-19
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16 nov 2020Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19 - A Randomized Clinical Trial
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16 nov 2020SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
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16 nov 2020Therapy for Early COVID-19A Critical Need
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12 nov 2020Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19 - A Randomized Clinical Trial
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12 nov 2020Misguided Use of Hydroxychloroquine for COVID-19 - The Infusion of Politics Into Science
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12 nov 2020Speed, Evidence, and Safety Characteristics of Vaccine Approvals by the US Food and Drug Administration
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2 nov 2020Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions
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2 nov 2020Shifting Hydroxychloroquine Patterns Raise Concern
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21 ott 2020Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia - A Randomized Clinical Trial
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21 ott 2020Time to Reassess Tocilizumab’s Role in COVID-19 Pneumonia - Editorial
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21 ott 2020Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19
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21 ott 2020Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia - A Randomized Clinical Trial
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19 ott 2020Sensible Medicine—Balancing Intervention and Inaction During the COVID-19 Pandemic
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19 ott 2020Postlicensure Evaluation of COVID-19 Vaccines
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19 ott 2020Answering Key Questions About COVID-19 Vaccines
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19 ott 2020Postapproval Vaccine Safety Surveillance for COVID-19 Vaccines in the US
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6 ott 2020Policy Implications of the Orphan Drug Designation for Remdesivir to Treat COVID-19
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1 ott 2020Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care WorkersA Randomized Clinical Trial
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30 set 2020In Vitro Efficacy of a Povidone-Iodine Nasal Antiseptic for Rapid Inactivation of SARS-CoV-2
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30 set 2020The Opioid Epidemic During the COVID-19 Pandemic
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30 set 2020Changes in Lung Cancer Treatment as a Result of the Coronavirus Disease 2019 Pandemic
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30 set 2020Analysis of Drug Test Results Before and After the US Declaration of a National Emergency Concerning the COVID-19 Outbreak
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17 set 2020Effect of Recombinant Human Granulocyte Colony–Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and Lymphopenia - A Randomized Clinical Trial
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17 set 2020Immune Stimulation With Recombinant Human Granulocyte Colony–Stimulating Factor for Coronavirus Disease 2019 (COVID-19)—Beware of Blind Spots
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14 set 2020Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19 - A Randomized Clinical Trial
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14 set 2020Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 - A Meta-analysis
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14 set 2020Emergency Use Authorizations During the COVID-19 Pandemic - Lessons From Hydroxychloroquine for Vaccine Authorization and Approval
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14 set 2020COVID-19 and mRNA Vaccines — First Large Test for a New Approach
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14 set 2020Corticosteroids in COVID-19 ARDS - Evidence and Hope During the Pandemic
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14 set 2020Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 - The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial
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14 set 2020Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19 - The CoDEX Randomized Clinical Trial
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31 ago 2020Rethinking Clinical Trials Reform During the COVID-19 Pandemic
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31 ago 2020Policy Implications of the Orphan Drug Designation for Remdesivir to Treat COVID-19
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31 ago 2020Case Rates, Treatment Approaches, and Outcomes in Acute Myocardial Infarction During the Coronavirus Disease 2019 Pandemic
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31 ago 2020Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity OutcomesInterim Analysis of 2 Randomized Clinical Trials
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31 ago 2020Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19A Randomized Clinical Trial
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31 ago 2020Efficacy of Remdesivir in COVID-19
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31 ago 2020Neutralizing Antibodies Against SARS-CoV-2—Important Questions, Unclear Answers
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31 ago 2020Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2
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3 ago 2020Characteristics and Strength of Evidence of COVID-19 Studies Registered on
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3 ago 2020Setting Expectations for Clinical Research During the COVID-19 Pandemic
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3 ago 2020COVID-19 and DexamethasoneA Potential Strategy to Avoid Steroid-Related Strongyloides Hyperinfection
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3 ago 2020Weighing the Benefits and Risks of Proliferating Observational Treatment AssessmentsObservational Cacophony, Randomized Harmony
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20 lug 2020Characteristics of the Multiplicity of Randomized Clinical Trials for Coronavirus Disease 2019 Launched During the Pandemic
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2 lug 2020Is a “Cytokine Storm” Relevant to COVID-19?
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29 giu 2020Colchicine for the Treatment of Myocardial Injury in Patients With Coronavirus Disease 2019 (COVID-19)—An Old Drug With New Life?
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29 giu 2020Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019The GRECCO-19 Randomized Clinical Trial
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29 giu 2020Missed Opportunities on Emergency Remdesivir Use
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26 giu 2020Monoclonal Antibodies for Prevention and Treatment of COVID-19
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26 giu 2020Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality
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9 giu 2020Risk of Hospitalization With Hemorrhage Among Older Adults Taking Clarithromycin vs Azithromycin and Direct Oral Anticoagulants
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8 giu 2020Combination of Ruxolitinib and Eculizumab for Treatment of Severe SARS-CoV-2-Related Acute Respiratory Distress Syndrome: A Controlled Study
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8 giu 2020How to Rapidly Determine First-in-Children Dosing for COVID-19 Therapeutics
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8 giu 2020Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019
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8 giu 2020Early Intervention of Palliative Care in the Emergency Department During the COVID-19 Pandemic
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8 giu 2020Coronavirus Disease 2019 and Opioid Use—A Pandemic Within an Epidemic
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8 giu 2020Outpatient Treatment at Home for Medicare Beneficiaries During and After the COVID-19 Pandemic
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8 giu 2020Correlation Between N95 Extended Use and Reuse and Fit Failure in an Emergency Department
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8 giu 2020Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19A Randomized Clinical Trial
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5 giu 2020A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19
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4 giu 2020Is there a Role for Inhaled Corticosteroids and Macrolide Therapy in Bronchiectasis?
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4 giu 2020Anti-inflammatory effects of macrolides—an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?
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4 giu 2020Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases
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1 giu 2020Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the United States
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1 giu 2020Weight-Based Dosing of Pembrolizumab Every 6 Weeks in the Time of COVID-19
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1 giu 2020Assessment of the Qualitative Fit Test and Quantitative Single-Pass Filtration Efficiency of Disposable N95 Masks Following Gamma Irradiation
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1 giu 2020Coronavirus Disease 2019 and Opioid Use—A Pandemic Within an Epidemic
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1 giu 2020Adverse Consequences of Rushing a SARS-CoV-2 VaccineImplications for Public Trust
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1 giu 2020Conducting Clinical Research During the COVID-19 PandemicProtecting Scientific Integrity
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1 giu 2020Using Controlled Trials to Resolve Key Unknowns About Policy During the COVID-19 Pandemic
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29 mag 2020Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19
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29 mag 2020Efficacy and safety of lopinavir/ritonavir or arbidol in adult patients with mild/moderate COVID-19: an exploratory randomized controlled trial
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26 mag 2020Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)An Unprecedented Partnership for Unprecedented Times
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26 mag 2020Coronavirus Disease 2019 (COVID-19) and Immune-Engaging Cancer Treatment
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26 mag 2020Need for Transparency and Reliable Evidence in Emergency Use Authorizations for Coronavirus Disease 2019 (COVID-19) Therapies
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26 mag 2020Planning for a COVID-19 Vaccination Program
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20 mag 2020Need for Transparency and Reliable Evidence in Emergency Use Authorizations for Coronavirus Disease 2019 (COVID-19) Therapies
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20 mag 2020Traditional Chinese medicine for treatment of coronavirus disease 2019: a review
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18 mag 2020SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults
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18 mag 2020Emergency Use Authorization of RemdesivirThe Need for a Transparent Distribution Process
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18 mag 2020Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State
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11 mag 2020The Equitable Distribution of COVID-19 Therapeutics and Vaccines
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11 mag 2020Cancer and Coronavirus Disease 2019 (COVID-19)—Facing the “C Words”
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11 mag 2020Palliative Care for Patients With Cancer in the COVID-19 Era
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11 mag 2020Understanding Observational Treatment Comparisons in the Setting of Coronavirus Disease 2019 (COVID-19)
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11 mag 2020Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19)
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11 mag 2020Randomized Clinical Trials and COVID-19Managing Expectations
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5 mag 2020Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19
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5 mag 2020A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
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4 mag 2020Assessment of QT Intervals in a Case Series of Patients With Coronavirus Disease 2019 (COVID-19) Infection Treated With Hydroxychloroquine Alone or in Combination With Azithromycin in an Intensive Care Unit
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4 mag 2020Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)
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30 apr 2020The race for coronavirus vaccines: a graphical guide
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30 apr 2020Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
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29 apr 2020Antibody responses to SARS-CoV-2 in patients with COVID-19
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27 apr 2020Management of COVID-19 Respiratory Distress
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27 apr 2020Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection - A Randomized Clinical Trial
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27 apr 2020Caution Needed on the Use of Chloroquine and Hydroxychloroquine for Coronavirus Disease 2019
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27 apr 2020Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China
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27 apr 2020Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents - A Systematic Review
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27 apr 2020Incidence of Adverse Drug Reactions in COVID‐19 patients in China: an active monitoring study by Hospital Pharmacovigilance System
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27 apr 2020Compassionate Use of Remdesivir for Patients with Severe Covid-19
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27 apr 2020Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
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27 apr 2020Probiotics and COVID-19: one size does not fit all
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27 apr 2020A real-time dashboard of clinical trials for COVID-19
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27 apr 2020Effect of the COVID-19 pandemic on cancer treatment and research
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27 apr 2020Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area
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27 apr 2020Segnalazione di sospette reazioni avverse ai medicinali nei pazienti con COVID-19. AIFA 21 aprile 2020
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27 apr 2020L’EMA richiama l’attenzione sul rischio di gravi effetti indesiderati con clorochina e idrossiclorochina. AIFA 23 aprile 2020
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27 apr 2020Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
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23 apr 2020COVID-19 Manual - AIMS
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21 apr 2020Should Patients Receiving ACE Inhibitors or Angiotensin Receptor Blockers be Switched to Other Antihypertensive Drugs to Prevent or Improve Prognosis of Novel Coronavirus Disease 2019 (COVID-19)?
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20 apr 2020Potential Shortages of Hydroxychloroquine for Patients with Lupus During the Coronavirus Disease 2019 Pandemic
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20 apr 2020Finding Effective Treatments for COVID-19 - Scientific Integrity and Public Confidence in a Time of Crisis
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20 apr 2020Meeting the Care Needs of Older Adults Isolated at Home During the COVID-19 Pandemic
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16 apr 2020Covid-19: WHO and South Korea investigate reconfirmed cases
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16 apr 2020Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
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16 apr 2020Temporal dynamics in viral shedding and transmissibility of COVID-19
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15 apr 2020Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
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15 apr 2020Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period
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15 apr 2020Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies
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15 apr 2020Structure of Mpro from COVID-19 virus and discovery of its inhibitors
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15 apr 2020Treatment of COVID-19: old tricks for new challenges
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14 apr 2020Official Statement of the section of Clinical Pharmacology of Italian Society of Pharmacology on Non-steroidal anti-inflammatory drugs (NSAIDs) and the increased risk of complications during infections with commentary
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14 apr 2020Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)
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14 apr 2020Official statement of the section of Clinical Pharmacology of the Italian Society of Pharmacology on the use of ACE- inhibitors or angiotensin receptor blockers in COVID-19 infection with commentary
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1 apr 2020Link to JAMA's published works on COVID-19
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31 mar 2020Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know
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27 mar 2020Antihypertensive drugs and risk of COVID-19?
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27 mar 2020Coronavirus: lethality in Italy between appearance and reality
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27 mar 2020Misguided drug advice for COVID-19
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23 mar 2020Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy
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18 mar 2020A Trial of Lopinavir Ritonavir in Adults Hospitalized with Severe Covid-19
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17 mar 2020A Coronavirus: three things all governments and their science advisers must do now
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13 mar 2020Care for Critically Ill Patients With COVID-19
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4 mar 2020Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics
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25 feb 2020Understanding of COVID‐19 based on current evidence
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19 feb 2020Breakthrough: Chloroquine Phosphate Has Shown Apparent Efficacy in Treatment of COVID-19 Associated Pneumonia in Clinical Studies
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13 mar 2003Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs
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The contents of this site are intended for purely informational purposes.
The Italian Society of Pharmacology (SIF) does not accept any responsibility for possible errors, forgetfulness, or bad interpretations present in these pages or in those referred to (link).